Research Description:
My main research interest is the unravelling of the mechanisms underlying chronic pain states, both in the central and peripheral nervous systems. I am particularly interested in arthritis and neuropathic pain models. Methods used in my lab include: immunocytochemistry at the light and electron microscopic levels, animal behaviour testing, and neurochemistry. I also have a major interest in the study of the effects of aging on the structure and function of the neocortex (in collaboration with Claudio Cuello).
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Selected Publications:
Articles
A. W. Saeed, and A. Ribeiro-da-Silva (2012) Non-peptidergic primary afferents are presynaptic to neurokinin-1 receptor immunoreactive lamina I projection neurons in rat spinal cord. Mol.Pain 8:64.
A. W. Saeed, and A. Ribeiro-da-Silva (2012) De novo expression of neurokinin-1 receptors by spinoparabrachial lamina I pyramidal neurons following a neuropathic lesion. Journal of Comparative Neurology, 2012 Nov 21. doi: 10.1002/cne.23267. [Epub ahead of print].
J.C. Peleshok, and A. Ribeiro-da-Silva (2012) Neurotrophic factor changes in the rat thick skin following chronic constriction injury of the sciatic nerve. Molecular Pain 8(1):1.
A.M. Taylor, M. Osikowicz, and A. Ribeiro-da-Silva (2012) Consequences of the ablation of nonpeptidergic afferents in an animal model of trigeminal neuropathic pain. Pain 153(6):1311-9.
S. Allard, T. Scardochio, A.C. Cuello, A. Ribeiro-da-Silva (2012). Correlation of cognitive performance nd morphological changes in neocortical pyramidal neurons in aging. Neurobiol Aging 13(7):1466-80.
S. Allard, W.C. Leon, P. Pakavathkumar, M.A. Bruno, A. Ribeiro-da-Silva, A.C. Cuello (2012) Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype. J Neurosci 32(6):2002-12.
A.M. Taylor and A. Ribeiro-da-Silva (2011) GDNF levels in the lower lip skin in rat model of trigeminal neuropathic pain: Implications for non-peptidergic fiber re-innervation and parasympathetic sprouting. Pain 152(7):1502-10.
S. Allard, V. Gosein, A. C. Cuello and A. Ribeiro-da-Silva (2011) Changes with aging in the dopaminergic and noradrenergic innervation of rat neocortex. Neurobiol Aging 32(12):2244-53.
L. Almarestani, M.A.Fitzcharles, G.J.Bennett, and A. Ribeiro-da-Silva (2011) Imaging studies in Freund's complete adjuvant model of regional polyarthritis, a model suitable for the study of pain mechanisms, in the rat. Arthritis Rheum 63(6):1573-81.
J. C. Peleshok and A. Ribeiro-da-Silva (2010) Delayed reinnervation by non-peptidergic nociceptive afferents of the glabrous skin of the rat hindpaw in a neuropathic pain model. J.Comp.Neurol. 519(1):49-63.
M. Cordero-Erausquin, S. Allard, T. Dolique, K. Bachand, A. Ribeiro-da-Silva, and Y. De Koninck (2009). Dorsal horn neurons presynaptic to lamina I spino-parabrachial neurons revealed by transynaptic labeling. J.Comp.Neurol. 517:601-615.
Book Chapters
A. Ribeiro-da-Silva and Y. De Koninck (2009). Morphological and neurochemical organization of the spinal dorsal horn. In: Science of Pain, edited by M. C. Bushnell and A. I. Basbaum, New York:Academic Press, p. 279-310.
A. J. Todd and A. Ribeiro-da-Silva (2007) Anatomical changes in the spinal dorsal horn after peripheral nerve injury. In: Molecular Pain, edited by M. Zhuo, Beijing:Higher Education Press/Springer Science, p. 309-324.
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