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MoulayAlaoui-Jamali

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MoulayAlaoui-Jamali

 

Position:Associate Member

Building:Lady Davis Institute for Medical Research
Room: 523
Phone: 514-340-8260/8222 Ext. 3438/3432
Fax:514-340-7576

E-mail: moulay.alaoui-jamali@mcgill.ca
Web Site: http://www.med.mcgill.ca/pharma/alaouijamalilab/

Education:PhD (Doctorat d'Etat Es-Sciences médicales) in experimental oncology and cancer pharmacology from René-Descartes and Lariboisiere/Sorbonne Universities in Paris, and the National Cancer Institute at Villejuif, France
Research Area:Cancer Pharmacogenomics & Target Discovery

Research Description:

Dr. Alaoui-Jamali received his PhD in 1986 in oncology from the National Cancer Institute at Villejuif, France. He also received a specialized training in cancer pharmacology, genetic toxicology, and clinical cancer pharmacology from Rene-Descartes and Krémlin-Bicetre Universities, Paris. He subsequently did his postdoctoral training at the Cancer Center of the Roswell Park Memorial Institute, University of New York in Buffalo, USA. His research has included a breadth of interdisciplinary studies spanning the fields of cancer biology, drug resistance, cancer models, and novel therapeutics. Recently his laboratory has begun to branch out further into the areas of genomic and proteomic applied to cancer progression and cancer targeting.

Publications:

Alaoui-Jamali MA, Bismar TA, Gupta A, Szarek WA, Su J, Song W, Xu Y, Xu B, Liu G, Vlahakis JZ, Roman G, Jiao J, Schipper HM. A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 2009 Oct 15;69(20):8017-24.

Alaoui-Jamali MA and Lougheed NC. Herbal products-chemotherapy drug interactions from a pharmacological perspective. In “Alternative and Complementary Therapies for Cancer: A Comprehensive Guide on Current Practice and Issues with Conventional Practice; Editors: M Alaoui-Jamali and Ling Peng. In press

Alaoui-Jamali M, Toliopoulos P, and Krikor B. Protein trafficking signalling in invasive cancers and therapeutic implications. "Signal Transduction in Cancer Metastasis". Cancer Metastasis Biology & Treatment Series by Springer Life Sciences–Biomedical Unit, 2009

Bijian K, Mlynarek AM, Balys RL, Jie S, Xu Y, Hier MP, Black MJ, Di Falco MR, Laboissiere S, Alaoui-Jamali MA. Serum Proteomic Approach for the Identification of Serum Biomarkers Contributed by Oral Squamous Cell Carcinoma and Host Tissue Microenvironment (dagger).
J Proteome Res. 2009 May 1;8(5):2173-2185.

Darnel AD, Behmoaram E, Vollmer RT, Corcos J, Bijian K, Sircar K, Su J, Jiao J, Alaoui-Jamali MA, Bismar TA. Fascin regulates prostate cancer cell invasion and is
associated with metastasis and biochemical failure in prostate cancer.
Clin Cancer Res. 2009 Feb 15;15(4):1376-83

Xu Y, Benlimame N, Su J, He Q, Alaoui-Jamali MA. Regulation of focal adhesion turnover by ErbB signalling in invasive breast cancer cells.
Br J Cancer. 2009 Feb 24;100(4):633-43.

Poondra RR, Kumar NN, Bijian K, Prakesch M, Campagna-Slater V, Reayi A, Reddy PT, Choudhry A, Barnes ML, Leek DM, Daroszewska M, Lougheed C, Xu B, Schapira M, Alaoui-Jamali MA, Arya P. Discovery of Indoline-Based, Natural-Product-like Compounds as Probes of Focal Adhesion Kinase Signaling Pathways. J Comb Chem. 2009 Jan 15.

Prakesch M, Bijian K, Campagna-Slater V, Quevillon S, Joseph R, Wei CQ, Sesmilo E, Reayi A, Poondra RR, Barnes ML, Leek DM, Xu B, Lougheed C, Schapira M, Alaoui-Jamali M, Arya P. Diverse architectures on the Indoline Scaffold: the discovery of a chemical probe of focal adhesion kinase signaling networks. Bioorg Med Chem. 2008 Nov 1;16(21):9596-602.

Behmoaram E, Bijian K, Jie S, Xu Y, Darnel A, Bismar TA, Alaoui-Jamali MA. Focal adhesion kinase-related proline-rich tyrosine kinase 2 and focal adhesion kinase are co-overexpressed in early-stage and invasive ErbB-2-positive breast cancer and cooperate for breast cancer cell tumorigenesis and invasiveness. Am J Pathol. 2008 Nov;173(5):1540-50.

Behmoaram E, Bijian K, Bismar TA, Alaoui-Jamali MA. Early stage cancer cell invasion: signaling, biomarkers and therapeutic targeting. Front Biosci. 2008 May 1;13:6314-25.

Benlimame N, He Q, Jie S, Xiao D, Xu YJ, Loignon M, Schlaepfer DD, and Alaoui-Jamali MA. FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion. Journal of Cell
Biology, in press.

Balys R, Alaoui-Jamali MA, Black M, and Hier M. A clinically relevant oral cancer model for serum proteomics eavesdropping on the tumor microenvironment.
Journal of Otolaryngology, in press.

Alaoui-Jamali MA, Scrivens PJ, and Loignon M. Stress-activated signal transduction pathways in DNA damage response: implications for repair, arrest, and therapeutic interventions. In "DNA Repair in Cancer
Therapy", Editors: L Panasci and MA Alaoui-Jamali, Humana Press Inc., NJ; 2004.

Alaoui-Jamali MA, Dupre I, Qiang H. Prediction of drug sensitivity and drug resistance in cancer by transcriptional and proteomic profiling. Drug Resistance Updates;7(4-5):245-255, 2004.

Brahimi F, Rachid Z, McNamee JP, Alaoui-Jamali MA, Tari AM, Jean-Claude BJ. Mechanism of action of a novel "combi-triazene" engineered to possess a polar functional group on the alkylating moiety: evidence for enhancement of potency. Biochem Pharmacol. 2005;70(4):511-9.

Mamane Y, Loignon M, Palmer J, Hernandez E, Cesaire R,
Alaoui-Jamali M, Hiscott J. Repression of DNA repair mechanisms in IRF-4-expressing and HTLV-I-infected T lymphocytes. J Interferon Cytokine Res. 2005;25(1):43-51.

Matheson SL, McNamee JP, Wang T, Alaoui-Jamali MA, Tari AM, Jean-Claude B. The combi-targeting concept: dissection of the binary mechanism of action of the combi-triazene SMA41 in vitro and antitumor activity in vivo. J. Pharmacology Experimental Therapeutics. 2004;311(3):1163-70.

Al Moustafa AE, Foulkes WD, Benlimame N, Wong A, Yen L, Bergeron J, Batist G, Alpert L, Alaoui-Jamali MA. E6/E7 proteins of HPV type 16 and ErbB-2 cooperate to induce neoplastic transformation of primary normal
oral epithelial cells. Oncogene, 2004 Jan15;23(2):350-8.

Mathonnet G, Lachance S, Alaoui-Jamali MA, Drobetsky EA. Expression of hepatitis B virus X oncoprotein inhibits transcription-coupled nucleotide excision repair in human cells. Mutation Res. 2004 Oct 4;554(1-2):305-18.

Chow TY, Alaoui-Jamali MA, Yeh C, Yuen L, Griller D. The DNA double-stranded break repair protein endo-exonuclease as a therapeutic target for cancer. Mol Cancer Ther. 2004 Aug;3(8):911-20.