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Contact
information:
Telephone: (514) 496-6384
e-mail address:
john.zwaagstra@nrc.ca
website:
http://bri-irb.nrc-cnrc.gc.ca/rd/health/receptors/activities_e.html
Projects for Thesis
Supervision:
1. Mechanisms of TGF-beta receptor
oligomerization and internalization.
2. Design and production of TGF-beta receptor-based
traps for imaging and therapeutics in cancer.
Recent
Publications:
Zwaagstra, J.C., Collins, C., Langlois, M.-J. and
O'Connor-McCourt, M.D.
Analysis of the contribution of receptor subdomains to the cooperative
binding and internalization of TGF-b
Type I and II receptors. Submitted to Experimental Cell Research.
De Crescenzo, G., Chao, H.,
Zwaagstra, J., Durocher, Y.
and O'Connor-McCourt, M.D. (2007)
Engineering TGF-b
traps: Artificially dimerizaed receptor ectodomains as high affinity
blockers of TGF-b
action. In: "Cancer Drug Discovery and Development: Transforming Growth
Factor-b
in Cancer Therapy", Vol. 2, edited by S.B. Jakowlew, Humana Press,
Totowa, N.J.
Ogorelkova, M.,
Zwaagstra, J.C., Elahi, S.M., Dias, C., Guilbault, C., Lo,
R., Collins, C., Jaramillo, M., Mullick, A., O'Connor-McCourt, M.D. and
Massie, B. (2006)
Adenovirus-delivered antisense RNA and siRNA exhibit different silencing
efficiencies for th eendogenous transforming growth factor-b
(TGFb)
Type II receptor. Oligonucleotides 16: 2-14.
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