Professor - Department of Medicine, Division of Experimental Medicine

Director, Division of Endocrinology and Metabolism, McGill University Health Centre

Contact information:

Telephone: (514) 398-4101
e-mail address: simon.wing@mcgill.ca
website: http://www.medicine.mcgill.ca/endomuhc/Wing/wing.html

Projects for Thesis Supervision:

1. Role of USP19 deubiquitinating enzyme in muscle wasting due to cancer cachexia.

2. Role of USP19 deubiquitinating enzyme in modulating sperm motility and fertilization.

3. Role of USP19 deubiquitinating enzyme in regulation of circadian rhythm.

Recent Publications:

Sundaram P, Pang Z, Miao M, Yu L, and Wing SS.
USP19 deubiquitinating enzyme regulates levels of major myofibrillar proteins in L6 muscle cells. Am. J. Physiol. 2009, 297: E1283-1290.

Lu Y, Adegoke OAJ, Nepveu A, Nakayama KI, Bedard N, Cheng D, Peng J, and Wing SS.

USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquiting ligase for p27^Kip1. Mol. Cell. Biol. 2009, 29: 547-558.

Bedard N, Hingamp P, Pang Z, Karaplis A, Morales C, Trasler J, Cyr D, Gagnon C, and Wing SS.
Mice lacking the UBC4-testis gene have a delay in postnatal testis development, but normal spermatogenesis and fertility. Mol. Cell. Biol. 2005, 25: 6346-6354.