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Contact
information:
Telephone: (514) 934-1934, ext.
44550
e-mail address: rima.slim@muhc.mcgill.ca
website:
www.mcgill.ca/files/humangenetics/SlimR.pdf
Projects for Thesis
Supervision:
1. Assess the functional role of NLRP7
mutations and variants in cells from the patients and in an in-vitro
cellular model. Determine their consequences on cellular death and
inflammation.
2. Determine whether NLRP7 mutations and
variants confer susceptibility to sporadic moles.
Recent
Publications:
Deveault, C., Qian, J., Chebaro, W., Ao, A.,
Gilbert, L., Mehio, A., Khan, R., Tan, S.L., Wischmeijer, A., Coullin,
P., Xie, X. and Slim, R.
(2008)
NLRP7 mutations in women with diploid androgentic and triploid
moles: a proposed mechanism for mole formation. Hum. Mol. Genet.
Djuric, U., El-Maarri, O., Lamb, B., Kuick, R.,
Seoud, M., Coullin, P., Oldenburg, J., Hanash, S. and
Slim, R. (2006)
Familial molar tissues due to mutations in the inflammatory gene,
NALP7, have normal postzygotic DNA methylation. Hum. Genet. 120:
390-395.
Murdoch, S., Djuric, U., Mazhar, B., Seoud, M.,
Khan, R., Kuick, R., Bagga, R., Kircheisen, R., Ao, A., Ratti, B.,
Hanash, S., Rouleau, G. and Slim, R.
(2006)
Mutations in NALP7, a maternal effect gene, result in recurrent
hydatidiform moles and reproductive wastage in humans. Nature Genet. 38:
300-302.
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