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NABIL SEIDAH

Professor – University of Montreal

Associate Member – Department of Medicine, Division of Experimental Medicine

Contact information:

Telephone: (514) 987-5609
e-mail address: nabil.seidah@ircm.qc.ca
website: http://www.ircm.qc.ca/fr/recherche/statique/unite26.html

Projects for Thesis Supervision:

1. The proprotein convertases PC5 and PCSK9 and their in vivo functions.

2. Structure-function and Proteomics identification of novel substrates of PC5, SKI-1 and PCSK9.

3. Cell based assays and inhibitor design of the proprotein convertases.


Recent Publications:

Benjannet S., Rhainds D., Essalmani R., Mayne J., Wickham L., Jin W., Asselin M.-C., Hamelin J., Varret M., Allard D., Trillard M., Abifadel M., Tebon A., Attie A.D., Rader D.J., Boileau C., Brissette L, Chrétien M., Prat A. and Seidah N.G.
NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the LDLR and LDL-cholesterol. J Biol Chem 279; 48865–48875, 2004.

Nour N., Mayer G., Mort J.S., Salvas A., Mbikay M., Morrison C.J., Overall C.M. and Seidah N.G.
The Cysteine-rich Domain of the Secreted Proprotein Convertases PC5A and PACE4 Functions as a Cell Surface Anchor and Interacts with Tissue Inhibitors of Metalloproteinases. Mol Biol Cell. (11):5215-26, 2005.

Essalmani R, Hamelin J, Marcinkiewwicz E, Chamberland A, Mbikay M, Chretien C, Seidah N.G. and Prat A.
Genetic deletion of PC/6 leads to early embryonic lethalithy. Mol. Cell. Biol. 2005 (in press).