Professor – Departments of Medicine and Oncology, Division of Experimental Medicine

Contact information:

Telephone: (514) 340-8260, ext. 4470
e-mail address: stephane.richard@mcgill.ca
website: http://www.ladydavis.ca/en/richardlab

Projects for Thesis Supervision:

1. Epigenetics: The laboratory now has projects related to biochemical and genetic characterization of the enzymes that catalyze arginine methylation.

2. DNA damage: The laboratory is currently studying projects that implicate protein methylation in the DNA damage response.

3. RNA binding proteins: The laboratory is currently studying proteins that implicate Sam68 in cancer metabolism and the role of the QKI RNA binding proteins in oligodendrocyte differentiation and CNS myelination.

Recent Publications:

Doukhanine, E., Gavino, C., Haines, J.D., Almazan, G. and Richard, S. (2010)
The QKI-6 RNA binding protein regulates AIP-1 mRNA stability during oligodendrocyte differentiation. Mol. Biol. Cell. [Epub ahead of print]

Huot, M.-E., Vogel, G. and Richard, S. (2009)
Identification of a Sam68 ribonucleoprotein complex regulated by epidermal growth factor. J. Biol. Chem. 284: 1903-1913.

Nicholson, T., Chen, T. and Richard, S. (2009)
The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation. Pharmacol. Res. 60: 466-474.

Yu, Z., Chen, T., Hebert, J., Li, E. and Richard, S. (2009)
A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol. Cell. Biol. 29: 2982-2986.