Professor – Departments of Medicine and Oncology, Division of Experimental Medicine

Contact information:

Telephone: (514) 340-8260, ext. 4470
e-mail address: stephane.richard@mcgill.ca
website: http://www.ladydavis.ca/en/richardlab

Projects for Thesis Supervision:

1. Projects related to biochemical and genetic charcterization of the enzymes that catalyze arginine methylation.

2. Projects that implicate protein methylation in the DNA damage response.

3. Projects that implicate Sam68 in cancer metabolism and the role of the QK1 RNA binding proteins in oligodendrocyte differentiation and CNS myelination.

Recent Publications:

Yu, Z., Vogel, G., Coulombe, Y., Dubeau, D., Spehalski, E., Hebert, J., Ferguson, D.O., Masson, J.Y. and Richard, S. (2012)
The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.  Cell Res. 22: 305-320.

Huot, M.E., Vogel, G., Zabarauskas, A., Ngo, C.T., Coulombe-Huntington, J., Majewski, J. and Richard, S.  (2012)
The Sam68 STAR RNA-binding protein regulates mTOR alternative splicing during adipogenesis. Mo. Cell. 46: 187-199.

Mallette, F.A., Mattiroli, F., Cui, G., Young, L.C., Hendzel, M.J., Mer, G., Sixma, T.K., And Richard, S. (2012)
RNF8-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitement to DNA damage sites. EMBO J. 31: 1865-1878.

Neault, M., Mallette, F.A., Vogel, G., Michaud-Levesque, J. and Richard, S. (2012)
Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor. Nucleic Acids Res. Aug. 16 [Epub ahead of print] Selected top 5% by NAR.