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Contact
information:
Telephone: (514) 934-1934, ext.
44580
e-mail address:
vassilios.papadopoulos@mcgill.ca
website:
Projects for Thesis
Supervision:
1. Understand the cellular and molecular
mechanisms responsible for the initiation and maintenance of steroid
biosynthesis in the gonads.
2. Examine the regulation of intracellular
compartmentalization and homeostasis of the precursor cholesterol and
steroid products by hormones and environmental factors.
3. Investigate the mechanisms underlying
neurosteroid synthesis in brain, in health and disease.
4. Examine the role of intracellular
compartmentalization and homeostasis of cholesterol in the progression
of cancer.
Recent
Publications:
Giatzakis C, Batarseh A, Dettin
L, Papadopoulos V.
The role of Ets transcription factors in the basal transcription of the
translocator protein (18kDa). Biochemistry In Press, 2007.
Li W, Hardwick M, Rosenthal DR,
Culty M, Papadopoulos V.
Peripheral-type benzodiazepine receptor overexpression and knockdown in
human breast cancer cells indicate its prominent role in tumor cell
proliferation. Biochemical Pharmacology 73: 491-503, 2007.
Liu J, Rone MB,
Papadopoulos V.
Protein-protein interactions mediate cholesterol transport into
mitochondria and steroid biosynthesis. J. Biol. Chem. 281: 38879-38893,
2006.
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