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Contact
information:
Telephone: (514) 934-1934, ext
35842
e-mail address:
alain.nepveu@mcgill.ca
website:
http://www.mcgill.ca/mog/research/nepveu/
http://www.medicine.mcgill.ca/oncology/displayoncology.asp?Oncology_ID=20
Projects for Thesis
Supervision:
1. Functions and
post-translational modulation of the CDP/Cux homeodomain proteins during
cell cycle progression.
2. Proteolytic processing of
CDP/Cux in normal cells and aberrant processing in cancer. Transgenic
mouse models are used to analyze the oncogenic potential of CDP/Cux
isoforms and to evaluate the contribution of certain proteases in
cancer.
3. Mechanisms of transcriptional
activation and repression by the CDP/Cux protein; modulation of DNA
binding and effector functions by post-translational modifications;
genomic approaches to identify targets of CDP/Cux in normal and cancer
cells.
Recent
Publications:
Santaguida, M, and
A. Nepveu.
Differential Regulation of CDP/Cux p110 by Cyclin A/cdk2 and Cyclin
A/cdk1. Journal of Biological Chemistry 280:32712-32721. 2005.
Goulet, B., A. Baruch, N.-S.
Moon, M. Poirier, L. Sansregret, A. Erickson, M. Bogyo, and
A. Nepveu.
A Cathepsin L Isoform that Is Devoid of a Signal Peptide Localizes to
the Nucleus in S Phase and Processes the CDP/Cux Transcription Factor.
Molecular Cell 14:207-219, 2004.
Truscott, M., L. Raynal, P.
Premdas, B. Goulet, L. Leduy, G. Bérubé, and
A. Nepveu.
CDP/Cux Stimulates Transcription from the DNA Polymerase
a
Gene Promoter. Molecular and
Cellular Biology 23 (8): 3013-3028. 2003.
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