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Contact
information:
Telephone: (514) 934-1553
e-mail address: jj.lebrun@mcgill.ca
website:
http://www.mcgill.ca/hcru/faculty/lebrun/
Projects for Thesis
Supervision:
1. Signaling pathways leading to breast cancer
metastasis.
2. Molecular mechanisms of tumor formation and
tumor suppression.
3. Signal transduction by the TGFb
family of growth factors.
Recent
Publications:
Lacerte, A., Korah, J., Roy, M.,
Yang, X.-J., Lemay, S. and Lebrun, J.-J.
Transforming growth factor-b tumor suppressor
effect on hTERT expression is mediated through increase of E2F-1
expression in a Smad/p38/Erk-dependent manner. Cell Signaling. In press,
2008.
Cocolakis, E., Dai, M. Drevet,
L., Ho, J., Haynes, E., Ali, S. and Lebrun,
J.-J.
Smad signaling antagonizes Stat5-mediated cell growth and
differentiation of mammary epithelial cells. J. Biol. Chem. In Press,
2008.
Ho, J., Cocolakis, E., dumas, V., Posner, B.,
Laporte, S.A. and Lebrun, J.-J.
(2005)
The G proteincoupled receptor kinase-2 is a TGFb-inducible
antagonist of TGF signal transduction. EMBO J. 24: 3247-3258.
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