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Contact
information:
Telephone: (514) 987-5593
e-mail address:
claude.lazure@ircm.qc.ca
website:
http://www.ircm.qc.ca/en/recherche/statique/unite29.html
http://www.ircm.qc.ca/microsites/clazure
Projects for Thesis
Supervision:
1. Chemical and structural
characterization of the endopeptidase PC1/3.
2. Organellar proteomics studies
focusing on endocrine secretory granules.
3. Development and applications
of a novel non-discrimatory method to identify and characterize cell
surface membrane-bound proteins.
Recent
Publications:
Gauthier, D.J. and
Lazure, C. (2008)
Complementary methods to assist subcellular fractionation in organellar
proteomics. Expert Review in Proteomics, 5: 603-617.
Gauthier, D.J., Sobota, J.A.,
Ferraro, F., Mains, R.E. and Lazure, C.
(2008)
Organellar proteomics in a day: Flow-cytometry-assisted purification and
proteomic analysis of the corticotropes dense-core secretory granules.
Mol. Proteomics, Proteomics, 8: 3848-3861.
Rabah, N., Wilkes, B.C.,
Gauthier, D.J. and Lazure, C. (2006)
Single amino acid substitution in the PC1/3 propeptide can induce
significant modifications of its inhibitory profile towards its cognate
enzyme. J. Biol. Chem. 281: 7556-7567.
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