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Contact
information:
Telephone: (514) 398-4487
e-mail address:
stephane.laporte@mcgill.ca
Projects for Thesis
Supervision:
1. Role of adaptors in the internalization and
signaling of the angiotensin type II receptors.
2. Regulation of the bradykinin B2 receptor
internalization and signaling.
3. Development of biosensor and use of real
time cell imaging for studying G protein-coupled receptor functions.
4. Study of cross talk between G
protein-coupled receptor and growth factor receptor signaling.
Recent
Publications:
Fessart D, Simaan M, Hamdan FF, Zimmerman B,
Comeau J, Wiseman PW, Bouvier M,
Laporte SA.
Src-dependent phosphorylation of beta2-adaptin dissociates the
beta-arrestin-AP-2 complex. J Cell Sci. 120: 1723-1732, 2007.
Claing A,
Laporte SA.
Novel roles for arrestins in GPCR biology and drug discovery. Curr Opin
Drug Dis & Develop. 8: 585-589, 2005.
Ho J, Cocolakis E, Dumas VM, Posner BI,
Laporte SA, Lebrun JJ.
The G protein-coupled receptor kinase-2 in a TGFb-inducible
antagonist of TGFb signal transduction. EMBO
J, 24: 3274-3258, 2005.
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