|
Contact
information:
Telephone: (514) 340-8222, ext.
3697
e-mail address:
antonis.koromilas@mcgill.ca
website:
http://www.medicine.mcgill.ca/oncology/displayoncology.asp?Oncology_ID=69
Projects for Thesis
Supervision:
1. Translational control by tyrosine
phosphorylation of eIF2alpha kinases.
2. Tumor suppressor p53 and environmental
stress.
3. Stat1 phosphorylation and control of
oncogenic signaling.
Recent
Publications:
Su, Q., Wang, S., Baltzis, D.,
Qu, L.K., Raven, J.F., Li, S., Wong, H.T. and
Koromilas, A.E. (2007)
Interferons induce the tyrosine phosphorylation of the eIF2a
kinase PKR through activation of Jak1 and Tyk2. Embo Reports 8: 265-270.
Kazemi, S., Mounir, Z., Baltzis,
D., Raven, J.F., Wang, S., Krishnamoorthy, J.L., Pluquet, O., Pelletier,
J. and Koromilas, A.E. (2007)
A novel function of the eIF2alpha kinases as inducers of the
phosphoinositide-3 kinase signaling pathway. Mol. Biol. Cell 18:
3635-3644.
Baltzis, D., Pluquet, O., Papadakis, A.I.,
Kazemi, S., Qu, L.K. and Koromilas,
A.E. (2007)
The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3
to promote the proteasomal degradation of P53. J. Biol. Chem. 282:
31675-31687.
|
