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Contact
information:
Telephone: (514) 340-8222, ext.
5285
e-mail address:
lawrence.kleiman@mcgill.ca
website:
http://www.mcgill.ca/hiv-assembly/
Projects for Thesis
Supervision:
1. HIV-1 assembly: Mechanism of GagPol
packaging.
2. HIV-1 replication: Inhibitors of annealing
to the viral RNA genome of the primer for reverse transcription,
tRNALys3.
3. HIV-1 replication: Role of lysyl-tRNA
synthetase in the HIV-1 life cycle.
Recent
Publications:
Guo F, Gabor J, Cen S, Hu K,
Mouland AJ, Kleiman L.
Inhibition of cellular HIV-1 protease activity by lysyl-tRNA synthetase.
J Biol Chem. 280: 26018-26023, 2005.
Wei M, Cen S, Niu M, Guo F,
Kleiman L.
Defective replication in HIV-1 when non-tRNALys3 primers are
used for reverse transcription. J Virol. 79: 9081-9087, 2005.
Cen S, Guo F, Niu M, Saadatman
J, Deflassieux J, Kleiman L.
The interaction between HIV-1 Gag and APOBEC3G. J Biol Chem. 279:
33177-33184, 2004.
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