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Contact
information:
Telephone: (514) 934-1934, ext.
35841
e-mail address:
bertrandj.jean-claude@mcgill.ca
website:
http://www.med.mcgill.ca/EXPMED/staff/jean-claude_bertrand.htm
Projects for Thesis
Supervision:
1. Mechanism of action of multi-targeted
anticancer drugs.
2. Synthesis and biological activities of
inhibitors of EGFR and bcr-abl.
3. Pharmacokinetics and biodistribution of
multitargeted anticancer drugs.
Recent
Publications:
Brahimi F, Rachid Z, McNamee JP,
Alaoui-Jamali MA, Tari AM, Jean-Claude BJ.
Mechanism of action of a novel "combi-triazene" engineered to possess a
polar functional group on the alkylating moiety: evidence for
enhancement of potency. Biochem Pharmacol. 70: 511-519, 2005. (link
to PDF version of this publication)
Katsoulas A, Rachid Z, Brahimi
F, McNamee J, Jean-Claude BJ.
Engineering 3-alkyltriazenes to block bcr-abl kinase: A novel strategy
for the therapy of advanced bcr-abl expressing leukemias. Leukemia Res.
29: 693-700, 2005.
Rachid Z, Brahimi F, Domarkas J,
Jean-Claude BJ.
Synthesis of half-mustard combi-molecules with fluorescence properties:
correlation with EGFR status. Bioorg Med Chem Lett. 15: 1135-1138, 2005.
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