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Contact
information:
Telephone: (514) 398-3864, ext.
00140
e-mail address:
elizabeth.fixman@mcgill.ca
website:
http://www.meakins.mcgill.ca/meakins/fixman/index.htm
Projects for Thesis
Supervision:
1. Nucleocytoplasmic shuttling of the STAT-6
transcription factor and regulation of gene expression.
2. Regulation of STAT-6 activity and allergic
airways disease by cell penetrating peptides targeting the STAT-6 SH2
domain.
3. Delivery of cytokines by gene modified T
cells as a tool to study airway inflammation and remodeling in
experimental asthma.
Recent
Publications:
Kinyanjui M.W., Tamaoka, M. and
Fixman, E.D. (2007)
T-helper type 2-dependent early recruitment of antigen non-specific CD4+
T cells in experimental asthma. Clin. Exp. Allergy 37: 1455-1466.
McCusker, C.T., Wang, Y., Shan, J.,
Kinyanjui, M., Villeneuve, A., Michael, H. and
Fixman, E.D. (2007)
Inhibition of experimental allergic airways disease by local application
of a cell penetrating dominant negative STAT-6 peptide. J. Immunol. 179:
2556-2564.
Ramos-Barbón, D., Presley, J.F., Hamid, Q.,
Fixman, E.D. and Martin,
J.G. (2005)
Antigen-specific CD4+ T cells drive airway smooth muscle remodeling in
experimental asthma. J. Clin. Invest. 115: 1580-1589.
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