|
Contact
information:
Telephone: (514) 987-5642
e-mail address:
javier.di.noia@ircm.qc.ca
website:
http://www.ircm.qc.ca/en/recherche/statique/unite47.html
Projects for Thesis
Supervision:
1.
The molecular mechanism of cytoplasmic retention of
Activation Induced Deaminase (AID). We are looking to identify and
characterize the molecules that prevent AID from freely diffusing into
the nucleus.
2.
Characterization
of novel members of the cytidine deaminase family with RNA and/or DNA
editing activity.
3.
The balance between
mutation and DNA repair during immunoglobulin gene diversification.
Recent
Publications:
Patenaude, A.-M., Orthwein, A., Yi, H., Campo,
V.A., Kavli, B., Buschiazzo, A. and Di
Noia, J.M. (2009)
Nuclear import and cytoplasmic retention of activation induced deaminase.
Nat. Struct. Mol. Biol. 16: 517-527.
Di Noia, J.M.,
Williams, G.T., Chan, D.T.Y., Buerstedde, J.M., Baldwin, G.S. and
Neuberger, M.S. (2007)
Dependence of antibody gene diversification on uracil excision. J. Exp.
Med. 204: 3209-3219.
Di Noia, J.M.,
Rada, C. and Neuberger, M.S. (2006)
SMUG1 is able to excise uracil from immunoglobulin genes: insight into
mutation versus repair. EMBO J. 5: 585-595.
|
