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Contact
information:
Telephone: (514) 496-1491
e-mail address: cunle.wu@cnrc.nrc.gc.ca
website:
http://www.irb-bri.cnrc-nrc.gc.ca/rd/health/genetics/index_e.html
Projects for Thesis
Supervision:
1. Investigate the mechanisms of osmosensing
and osmoregulation using genetic, biochemical as well as synthetic
biology approaches to manipulate signal transduction pathways in model
organism yeast Saccharomyces cerevisiae and related organisms.
2. Investigate the function of membrane-mucine
and associated molecules in the regulation of MAP kinase pathways
governing cell differentiation and response to osmotic stresses.
3. Study the mechanisms controlling the pathway
specificity and cross-talk among pathways with major focus on the
scaffold/adaptor - kinase structure-function relationship of several MAP
kinase pathways that are involved in cell proliferation ,
differentiation as well as response to stress conditions in yeast.
Recent
Publications:
Wu, C.,
Jansen, G., Zhang, J., Thomas, D.Y. and Whiteway, M. (2006)
Adaptor protein Ste50p links the Ste11p MEKK to the HOG pathway through
plasma membrane association. Genes and Dev. 20: 734-746.
Jansen, G.,
Wu, C., Thomas, D.Y. and Whiteway, M. (2005)
A vector system for Drag & Drop cloning in yeast. Gene 344: 43-51.
Wu, C.,
Arcand, M., Jansen, G., Zhong, M., Thomas, D.Y., Meloche, S. and
Whiteway, M. (2003)
Phosphorylation of Ste50p, a regulator of the MAPKKK Ste11p by casein
kinase I is required for proper mating function in Saccharomyces
cerevisiae. Eukaryotic Cell 2: 949-961.
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