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Contact
information:
Telephone: (514) 987-5647
e-mail address:
jean-francois.cote@ircm.qc.ca
website:
http://www.ircm.qc.ca/microsites/cytosquelette/en/
Projects for Thesis
Supervision:
1.
Understanding the role of the DOCK180-Rac1 signaling pathway during
myoblast cell-cell fusion.
2.
Structural
and functional studies to understand the mode of auto-regulation of the
Rac regulator ELMO.
3.
Understanding the contribution of joint integrin-ErbB2 signaling in
breast cancer cell migration and invasion using cell lines and mouse
models.
Recent
Publications:
Premkumar, L., Bobkov, A.A., Patel, M.,
Jaroszewski, L., Bankston, L.A., Stec, B., Vuori, K.,
Côté, J.-F. and Liddington,
R.C. (2010)
Strcural basis of membrane-targeting by the Dock180 family of Rho-family
guanine exchange factors (RhoGEFs). J. Biol. Chem. (Epub ahead of print
- CIHR, MOP-77591).
Côté, J.-F.
and Vuori, K.
(2009)
Two lipids that give direction. Science 324: 346-347.
Laurin, M., Fradet, N., Blangy, A., Hall, A.,
Vuori, K. and Côté, J.-F.
(2008)
The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in
vivo. P.N.A.S. 104: 15446-15451.
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