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Contact
information:
Telephone: (514) 987-5804
e-mail address: eric.cohen@ircm.qc.ca
website:
www.ircm.qc.ca/en/recherche/statique/unite36.html
Projects for Thesis
Supervision:
1. Molecular and cellular processes underlying
the antagonizing effect of HIV-1 viral protein U (Vpu) on tetherin, an
IFN-regulated restriction factor that suppresses HIV-1 release.
2. Identification of novel host cell factors
restricting HIV infection in macrophages and dendritic cells that are
regulated by the accessory proteins Vpr/Vpx.
3. HIV-host cell interactions governing viral
assembly, release and transmission.
Recent
Publications:
Dube, M., Roy, B.B.,
Guiot-Guillain, P., Binette, J., Mercier, J., Chiasson, A. and
Cohen, E.A. (2010)
Antagonism of tetherin restriction of HIV-1 release by Vpu involves
binding and sequestration of the restriction factor in a perinuclear
compartment. PLoS Pathogens, April 2010.
Belzile, J.-P., Richard, J., Rougeau, N., Xiao,
Y. and Cohen, E.A.
(2010)
HIV-1 Vpr induces the K-48-linked polyubiquitination and degradation of
target cellular proteins to activate ATR and promote G2-arrest. J. Virol.
Published ahead of print on 20 January 2010 as doi:10.1128/JVI.02590.09.
Richard, J., Sindhu, S., Pham, T., Belzile,
J.-P. and
Cohen, E.A. (2009)
HIV-1 Vpr upregulates expression of ligands for the activating NKG2D
receptor and promotes NK cell-mediated killing. Blood 115: 1354-1363.
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